Rad4/Cut5 is a scaffold protein in the Chk1-mediated DNA damage checkpoint in S.pombe.However, whether Utensils it contains a robust ATR-activation domain (AAD) required for checkpoint signaling like its orthologs TopBP1 in humans and Dpb11 in budding yeast has been incompletely clear.To identify the putative AAD in Rad4, we carried out an extensiv
Abstract Nano and microfluidic technologies have shown great promise in the development of controlled drug delivery systems and the creation of microfluidic devices with logic-like functionalities.Here, we focused on investigating a droplet-based logic gate that can be used for automating medical diagnostic assays.This logic gate uses viscoelastic
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain.Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for Serums this rare syndrome.Many malignant and metastatic neoplasms are causing this syndrome,
The advancement of neuroscience, perhaps the most information rich discipline of all the life sciences, requires basic frameworks for organizing the vast amounts of data generated by the research community to promote novel insights and integrated understanding.Since Cajal, the neuron remains a fundamental unit of the nervous system, yet even with t
Adults of the invasive harlequin ladybird, Harmonia axyridis (Coleoptera: Coccinellidae), were found to be parasitized by nematodes (Tylenchomorpha: Allantonematidae) in Denmark.The nematodes were Utensils identified as Parasitylenchus sp.Major morphological characters of the nematodes did not differ significantly from Parasitylenchus coccinellinae